Four men working at a remote scientific outpost unravel the disturbing secrets about the facility's history, signaling the approach of a mysterious menace that will not only consume these men, but, perhaps, everyone on the planet.

Recognizing the destructive power of its captive giant Ape, the military makes its own battle-ready A.I., Mecha Ape but its first practical test goes horribly wrong, leaving the military no choice but to release the imprisoned giant ape to stop the colossal robot before it destroys downtown Chicago.